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Two-carbon nitrogen ring bases (adenine and guanine) covalently linked to a sugar (ribose or deoxyribose); can function as extracellular messengers, antimetabolites, and chain terminators that inhibit viral DNA polymerase.
2 -Deoxyadenosine monohydrate (CAS No 16373-93-6) is widely used in biomedical research particularly in molecular biology and pharmacology studies This compound originates from the deoxyribonucleic acid (DNA) and acts by integrating into DNA strands impacting replication and cellular processes It targets pathways involved in nucleoside metabolism and DNA synthesis In vitro it demonstrates activity typically in the nanomolar to low micromolar range making it valuable for studying DNA replication and repair mechanisms Common applications include cell-based assays animal studies and drug screening to investigate its effects on cellular proliferation and apoptosis Experimental concentrations typically depend on the specific research design
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6-O-Propynyl-2-deoxyguanosine (CAS 1640051-47-3) is a modified nucleoside featuring an alkyne functional group at the 6-position of deoxyguanosine This structural modification enables its use in bioorthogonal click chemistry reactions facilitating site-specific labeling and conjugation in nucleic acid research The alkynyl group serves as a chemical handle for copper-catalyzed azide-alkyne cycloaddition allowing researchers to attach probes or other functional molecules 6-O-Propynyl-2-deoxyguanosine is utilized for studying DNA structure dynamics and for the development of modified oligonucleotides in biochemical and molecular biology assays
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If you are unable to find the chemical you are looking for, make sure you are logged into your fishersci.com account and click on the following link: eMolecules Building Block Tool
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Also available in 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. 5'-Deoxyadenosine (5′-dAdo) is an oxidized nucleoside found in the urine of normal subjects. Oxidized nucleosides represent excellent biomarkers for determining the extent of damage in genetic material which has long been of interest in understanding the mechanism of aging neurodegenerative diseases and carcinogenesis. The normal form of deoxyadenosine used in DNA synthesis and repair is 2'-deoxyadenosine where the hydroxyl group (-OH) is at the 2' position of its ribose sugar moiety. 5'-deoxyadenosine has its hydroxyl group at the 5' position of the ribose sugar. purity: 99%
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A prodrug form of 2-F-adenine; reduces mean tumor weight in an E. coli purine nucleoside phosphorylase-expressing D54 glioblastoma mouse xenograft model at 100 mg/kg
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